Development of PSMA x CD3 T-cell engagers using an integrated, functional approach 

de Puyraimond V, et al. American Association for Cancer Research® (AACR) Annual Meeting, April 2024

This poster describes the generation of PSMA x CD3 T-cell engagers (TCEs) for the treatment of castration-resistant prostate cancer. A function-first approach was used to identify TCEs that show significantly lower cytokine release than clinical benchmarks while maintaining potent killing of PSMA-expressing cancer cell lines.

DOI: 10.1158/1538-7445.AM2024-6359

Further reading:

1. Mai M, et al. J Immunother Cancer 2023;11(Suppl 1):A1–A1731.