Profiling bispecific T-cell engagers: Strategies for enhancing potency while minimizing cytokine release
Scientific Case Studies
Presentations & Posters
Diverse CD28-binding antibodies for costimulatory T-cell engager development
Development of PSMA x CD3 T-cell engagers using an integrated, functional approach
Target-dependent considerations for the design of bispecific T-cell engagers
Functional and specific T-cell engagers for a peptide-MHC tumor target
Discovery of diverse GPCR-targeted antibodies using integrated technologies
A rational approach for selecting CD3-binding antibodies for T-cell engager development
Targeting intracellular tumor antigens to fight cancer: discovery and development of functional and specific T-cell engagers against a MAGE-A4 pMHC
Identifying T-cell engagers with optimal potency and cytokine-release profiles with a diverse panel of CD3-binding antibodies
Breaking barriers to access intracellular targets with T-cell engagers: Discovery of diverse, developable, and ultra-specific antibodies against a MAGE-A4 pMHC
Publications
Developability considerations for bispecific and multispecific antibodies
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230
Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes