Functional and specific T-cell engagers for a peptide-MHC tumor target 

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Tortora D, et al. American Association for Cancer Research® (AACR) Annual Meeting, April 2024

This poster describes data on the generation of T-cell engagers (TCEs) targeting the peptide-MHC MAGE-A4. To date, the target repertoire for TCEs has been restricted to proteins expressed on the surface of cancer cells. Intracellular peptides displayed on MHC class I (pMHCs) would greatly expand the target pool for TCEs, yet development of TCEs against pMHCs has been limited due to the high degree of target specificity required. The data presented illustrates how AbCellera’s platform is unlocking this target class by generating molecules with high specificity for MAGE-A4-pMHC and little to no binding to hundreds of off-target pMHCs.

DOI: 10.1158/1538-7445.AM2024-2373

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Further reading: 

  1. Tortora D, et al. J Immunother Cancer 2023;11(Suppl 1):A1–A1731.
  2. Tortora D, et al. Cancer Res (2023) 83 (7_Supplement): 1891.