Our Focus

Driven by science, focused on people.

Our Pipeline

We are advancing antibody drug programs across multiple indications and modalities.

Molecule
Therapeutic Area
Stage of Development
Target
NK3R
GPCR
Indication
Vasomotor Symptoms (VMS)
Overview
ABCL635 is a potential first-in-class antibody medicine for the non-hormonal treatment of VMS (commonly known as hot flashes) associated with menopause. ABCL635 specifically targets NK3R, a clinically validated complex membrane protein found on KNDy neurons in the infundibular nucleus of the hypothalamus that helps regulate body temperature. ABCL635 is the first AbCellera-led program generated using our GPCR and ion channel technologies. It is currently being studied in a phase 1 trial to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, and the frequency and severity of VMS with subcutaneous doses of ABCL635.
Program Type
Internal
Target
OX40L
Indication
Atopic Dermatitis (AD)
Overview
ABCL575 is an investigative monoclonal antibody for the treatment of moderate-to-severe atopic dermatitis (AD), with potential applications to other inflammatory and autoimmune conditions. ABCL575 binds OX40L to disrupt OX40/OX40L signaling, a regulator of inflammatory pathways in AD. It has been engineered with a modified Fc domain to support Fc-silencing and half-life extension. In preclinical studies, ABCL575 shows potent inhibition of T cell-mediated inflammatory pathways, favorable tolerability, and an in vivo half-life that is expected to support less frequent dosing than current clinical-stage molecules. A phase 1 clinical trial was initiated in Q3 of 2025 to assess safety and tolerability in healthy participants following subcutaneous doses of ABCL575.
Program Type
Internal
Target
Undisclosed
GPCR / Ion Channel
Indication
Undisclosed
Overview
ABCL688 is a potential antibody medicine targeting a multipass complex membrane protein for the treatment of an undisclosed indication in autoimmunity. ABCL688 is the second AbCellera-led program generated using our GPCR and ion channel technologies, and the program entered IND-enabling studies in Q2 of 2025.

Program Type
Internal

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