Address unmet medical need with antibodies for
tough targets.
Finding functional antibodies for
GPCRs and ion channels.
GPCRs AND ION CHANNELS ARE INVOLVED IN A WIDE RANGE OF DISEASES.
GPCRs and ion channels are critical proteins in the human body.
But when they malfunction, they can lead to an array of conditions, including cancer, inflammation, pain, and diseases that impact the lungs, eyes, heart, and more.
Antibodies can help. Compared to small molecule drugs, antibody medicines:
Cause fewer side-effects because they’re less likely to bind the wrong targets.
Can be taken less often because they last longer in the body.
GPCRs and ion channels are challenging targets.
They’re hard to make.
They’re unstable, making them challenging to work with in the laboratory
They’re difficult for cells to produce, limiting their availability as research tools
They change shape, making it difficult to find antibodies that bind the right conformation
They’re hard to hit.
Their target space is tiny, with very few regions for antibodies to bind
They’re not seen as threats by immune cells, limiting antibody responses against them
They’re highly similar to one another, making it difficult to find antibodies that target just one
Discovery of anti-GPCR antibodies more potent than a clinical benchmark, in just 8 months.
We broke the technological and biochemical barriers — producing proteins, driving immune responses, and finding hits — that have traditionally limited antibody discovery for GPCRs and ion channels.
BREAK THE BARRIERS OF CONVENTIONAL DISCOVERY WITH PURPOSEFULLY BUILT TECHNOLOGY.
Maximize antibody output.
- Use multiple immunization formats with genetic and protein formulations
- Break tolerance with proprietary immunization strategies
- Enhance diversity by searching multiple immune compartments from a variety of species
Find the ones that work.
- Find ultra-rare hits with microfluidic single-cell screening
- Test more candidates with high-throughput expression and characterization
- Pinpoint promising leads with highly specialized functional assays and developability assessments