AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.
We are looking for an experienced and motivated Research Scientist who is looking for opportunities in a fast-paced protein science team that is focused on identifying lead therapeutic antibody molecules for clinical development. You are an individual who brings an in-depth understanding of molecular interactions and exceptional skills in biophysics, to characterize the kinetics, affinity, and molecular mechanism of action of antibody based therapeutic molecules to drive lead selection for clinical development. You will be motivated by an opportunity to collaborate with teams from across the organization including early discovery, translational sciences, pre-clinical development, and CMC, to build a fully integrated next generation antibody drug discovery platform that can rapidly turn biological hypothesis into a therapeutic lead molecule that is ready for clinical testing.
How you might spend your days:
- Using biosensor based technologies such as surface plasmon resonance (SPR) or biolayer interferometry (BLI) to rapidly screen through hundreds to thousands of candidate antibodies to identify lead molecules with desired kinetic, affinity and epitope profiles
- Conducting detailed characterization of the kinetics, affinity, and mechanism of action of lead molecules, including for example, assessing pH-dependent binding, Fc effector function, and other critical properties
- Evaluating the properties of bispecific antibodies and other multispecific molecules, in support of lead selection and optimization
- Developing high throughput workflows for antibody kinetic and epitope analysis, and automating these workflows using liquid handlers
- Working with data scientists, machine learning and software engineers to streamline the capture, curation and analysis of large data sets
- Collaborating with teammates from discovery biology, protein engineering and other teams to build platforms and processes, as well as analyze, interpret and communicate data
- Providing protein science and biotherapeutic leadership within multidisciplinary drug discovery teams
- Mentoring and developing junior scientists within a rapidly growing and dynamic team
We'd love to hear from you if:
- You are energized by working with teammates to develop innovative workflows that revolutionize the speed and quality of therapeutic antibody discovery and optimization
- You have a solid understanding of surface plasmon resonance (SPR) or other biosensor techniques, with application to evaluating antibody or other protein interactions
- You have a PhD in Biophysics, Biochemistry, or Structural Biology, or a MSc degree plus 5+ years of relevant experience
- You have demonstrated experience using Carterra, Biacore, and Octet platforms to characterize protein binding kinetics, affinity and epitope
- You have experience running plate based assays, analyzing large data sets, and interpreting and communicating data in the context of broader project objectives
- You have impeccable attention to detail with excellent documentation and organizational skills
- You have effective decision-making and troubleshooting skills, with impeccable attention to detail
- You have great interpersonal skills with the ability to work collaboratively as a member of cross-functional team
- You have experience using analytical techniques such as UHPLC, light scattering or mass spectrometry to assess reagent quality and aid in the interpretation of binding data (desirable)
- You have experience using automated liquid handlers, or other molecular interaction technologies such as kinetic exclusion assay (KinExA), enzyme-linked immunosorbent assay (ELISA), or isothermal titration calorimetry (ITC) (desirable)
What we offer:
AbCellera’s hiring range for this role is CAD $75,200 - $94,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.
You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find we prioritize teams and social groups to build community and connections across AbCellera.
About AbCellera:
AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.
And it all starts with our team. We’ve built a place where people feel they are part of something bigger than themselves. A place that exists to push the limits of science and technology, and aims to bring better therapies to patients.
We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success.
To apply:
Please submit your application through our website and refer to Job ID 23228 in your cover letter. We apologize in advance, but we receive a large volume of applications and are only able to contact those who are selected for an interview.
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