Identifying T-cell engagers with optimal potency and cytokine-release profiles with a diverse panel of CD3-binding antibodies

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Mai M, et al. American Association for Cancer Research® (AACR) Annual Meeting, April 2023

This poster provides a comprehensive data package on a panel of novel, fully human CD3-binding antibodies, including binding and functional comparisons to molecules commonly used for T-cell engager (TCE) development. Proof-of-concept data illustrates how these antibodies could enable the development of optimal TCEs for different tumor targets.

DOI: 10.1158/1538-7445.AM2023-1886

AbCellera AACR 2023 Poster - T-cell Engager Platform
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Further reading:

  1. DeVorkin L, et al. Cancer Res (2022) 82 (12_Supplement): 312.
  2. DeVorkin L, et al. J Immunother Cancer 2022;10(Suppl 2):A1–A1603.
  3. Bergqvist P, et al. J Immunother Cancer 2024;12(Suppl 2):A1–A1683.
  4. Mai M, et al. Cancer Res (2024) 84 (6_Supplement): 1868.
  5. Mai M, et al. J Immunother Cancer 2023;11(Suppl 1):A1–A1731.