Target-dependent considerations for the design of bispecific T-cell engagers 

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Mai M, et al. American Association for Cancer Research® (AACR) Annual Meeting, April 2024

This poster describes the generation of T-cell engagers (TCEs) for three solid tumor targets, PSMA, B7-H4, and 5T4, with functional profiles that are differentiated from clinical benchmarks. Molecules were engineered using a set of rare CD3-binding antibodies that consistently show potent tumor-cell killing and low cytokine release across multiple targets, demonstrating their potential to expand the therapeutic window across solid tumor indications.

DOI: 10.1158/1538-7445.AM2024-1868

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Further reading: 

  1. Bergqvist P, et al. J Immunother Cancer 2024;12(Suppl 2):A1–A1683. 
  2. Mai M, et al. J Immunother Cancer 2023;11(Suppl 1):A1–A1731. 
  3. Mai M, et al. Cancer Res (2023) 83 (7_Supplement): 1886. 
  4. DeVorkin L, et al. Cancer Res (2022) 82 (12_Supplement): 312. 
  5. DeVorkin L, et al. J Immunother Cancer (2022)10 (Suppl 2):A1–A1603.